| Autor: | Victor A. Tutelyan, L. V. Kravchenko, Avren'eva Li, A. L. Posdnyakov, G. V. Guseva |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Toxin General Medicine Pharmacology Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Carboxylesterase Enzyme chemistry Intestinal mucosa Biochemistry Detoxification Toxicity medicine Mycotoxin Drug metabolism |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 131:544-547 |
| ISSN: | 0007-4888 |
| DOI: | 10.1023/a:1012346401315 |
| Popis: | Experiments on Wistar rats showed that feeding a ration containing 0.1% concentrate of food indoles (indole-3-carbinole and ascorbigen) for 3 weeks increased activity of phases I and II xenobiotic metabolism enzymes in the liver and intestinal mucosa and weakened the toxic effects of trichothecene T-2 mycotoxin. Activity of the key enzymes of T-2 detoxification, microsomal carboxylesterase and UDP-glucuronosyl transferase, was 1.5-2-fold higher in rats receiving T-2 toxin against the background of indole-enriched diet compared to toxin-treated rats kept on standard ration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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