Discovery of novel allosteric inhibitors of HCV NS3/4a enzyme via structure-based drug design

Autor:	H. Jhoti, J.R. Yon, A.J. Woodhead, M.G. Carr, C. Richardson, Neil T. Thompson, P. Pathuri, R. McMenamin, Joseph E. Coyle, S. Saalau-Bethell, M. Verdonk, Sharna J. Rich, Christopher William Murray, C.C.F. Hamlett, David C. Rees, B. Graham, P.A. Williams, G. Chessari, S. Hiscock, M. Vinkovic, M. Frederickson, M. Reader, F.P. Holding
Rok vydání:	2012
Předmět:	Structural Biology media_common.quotation_subject Allosteric regulation Art history Structure based Art media_common
Zdroj:	Acta Crystallographica Section A Foundations of Crystallography. 68:s27-s27
ISSN:	0108-7673
DOI:	10.1107/s0108767312099473
Popis:	NS3/4a enzyme via structure-based drug design Puja Pathuri, Susanne M. Saalau-Bethell, Andrew J. Woodhead, Maria G. Carr, Gianni Chessari, Joseph Coyle, a Martyn Frederickson, Brent Graham, Chris Hamlett, Steven D. Hiscock, Finn P. Holding, Harren Jhoti, Rachel McMenamin, Chris W. Murray, Mike Reader, David C. Rees, Sharna J. Rich, Caroline J. Richardson, Neil Thompson, Marcel L. Verdonk, Mladen Vinkovic, Pamela A. Williams, Jeff Yon Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge, CB4 0QA, UK E-mail: Puja.Pathuri@astx.com
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bbd7909058a44075d77af7fa1e52dd3f https://doi.org/10.1107/s0108767312099473 Zobrazit plný text záznamu Plný text