| Popis: |
Cancer chemoprevention involves the chronic administration of a natural, synthetic, or biological agent to delay or prevent the occurrence of malignancy. Since ancient times, plant-derived compounds, the so-called phytocompounds, have been used to prevent or treat several diseases including cancer. The potential use of phytocompounds against various cancers like lung, breast, colon, etc. has been demonstrated in preclinical and clinical studies. In the last decade, strategies of chemoprevention have changed significantly, and now have rigorous selection criteria involving more extensive preclinical mechanistic evaluation of agents before clinical trials are instituted and a focus on defining biomarkers of activity that can be used as early predictors of efficacy. In this review, we discuss the preclinical and clinical studies of selected promising chemopreventive agents and also summarize newly emerging compounds and highlight potential new developments in the field of chemoprevention. |
