Ekstrak buah makasar (Brucea Javanica (L) Mer.) meningkatkan kadar enzim Superoksida Dismustase (SOD) mencit (Mus musculus) Swiss Webster jantan yang diinduksi paraquat

Autor: Maria Eka Patri Yulianti
Rok vydání: 2020
Předmět:
Zdroj: Intisari Sains Medis. 11:996-999
ISSN: 2503-3638
2089-9084
DOI: 10.15562/ism.v11i3.743
Popis: Background: Aging is a biological process where one of the contributing factors is oxidative stress due to free radicals in the body. Paraquat is an example of free radicals that are often used by oil palm plantation farmers in Bengkulu, which can trigger the aging process by reducing the enzyme Superoxide Dismutase (SOD). The provision of fruit extract of Makassar (Brucea javanica (L) Mer) contains bioactive compounds that can function as antioxidants by increasing SOD levels in the body. This study aims to prove that the fruit extract can increase the levels of SOD of male Swiss Webster mice induced by paraquat.Methods: In vivo experimental research with randomized pretest-posttest control group design was conducted on 14 Swiss Webster mice (Mus musculus) as research subjects. The research subjects were then divided into 2 groups, namely the control and the treatment group (20 mg/kgBW/day (P1) for 14 days). Data were analyzed using SPSS version 17 for Windows.Results: The results showed that there was no significant increase in the mean of SOD levels either before (16.97±1.45 U/ml) or after (17.07±1.89 U/ml) treatment in the P0 group (p> 0.05). However, in the P1 group that was given paraquat induction coupled with Makassar fruit extract at a dose of 20 mg/kgBW/day for 14 days, it showed that there was a significant increase in the mean SOD levels from 17.18±1.69 U/ml to 67.56±3.65 U/ml (p 0,05). Akan tetapi, pada kelompok P1 yang diberikan induksi paraquat ditambah dengan ekstrak buah makasar dengan dosis 20 mg/kgBB/hari selama 14 hari menujukkan terdapat peningkatan secara bermakna rerata kadar SOD dari 17,18±1,69 U/ml menjadi 67,56±3,65 U/ml (p
Databáze: OpenAIRE
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