Ca2+ Channel Currents Inhibited by Serum from Select Patients with Guillain-Barré Syndrome

Autor:	H. Yoshino, Tadashi Miyatake, T. Nagaoka, Keiko Hoshi, Keiko Tanaka, K. Kawakami, Yoshihiko Nakatani, Iku Utsunomiya, Kyoji Taguchi
Rok vydání:	2006
Předmět:	Guillain-Barre syndrome business.industry Spinal cord medicine.disease Acute motor axonal neuropathy Electrophysiology medicine.anatomical_structure Neurology Muscle action Acute Inflammatory Demyelinating Polyneuropathy Anesthesia Medicine Ca2 channels Neurology (clinical) business
Zdroj:	European Neurology. 57:11-18
ISSN:	1421-9913 0014-3022
Popis:	We performed an electrophysiological study demonstrating inhibition of spontaneous muscle action potentials within a coculture of rat muscle and spinal cord by exposure to serum, as well as purified IgG, from patients with the acute motor axonal neuropathy (AMAN) variant of Guillain-Barré syndrome (GBS). However, exposure to serum from two patients with the acute inflammatory demyelinating polyneuropathy (AIDP) form of GBS had no effect. Using a whole-cell recording technique, we then investigated the effects of serum and purified IgG from patients with GBS on voltage-dependent calcium channel (VDCC) currents in nerve growth factor-differentiated PC12 cells. Serum from patients with GBS (AMAN) inhibited VDCC currents in PC12 cells, which was fully reversible by washing with the bath solution. Similarly, purified IgG from the serum of two patients with GBS (AMAN) also inhibited VDCC currents in PC12 cells. In contrast, sera from patients with AIDP and healthy volunteers did not affect VDCC currents in PC12 cells. These results suggest that muscle weakness in some patients with GBS might be induced by inhibition of Ca2+ channel currents within motor nerve terminals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bbc2cc2936a25b70875a241c1ec2aa2a https://doi.org/10.1159/000097004 Zobrazit plný text záznamu