A NEW THREE-DIMENSIONAL Co(II)-BASED COORDINATION POLYMER: TREATMENT ACTIVITY IN OBESITY MODEL IN VITRO AND IN VIVO BY INCREASING THE LEVEL OF LEPTIN
| Autor: | D Q Mao, Y Chen, G Xiao, N Li, Q D Ye, Q Y Dai, S Z Cui |
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| Rok vydání: | 2020 |
| Předmět: |
Stereochemistry
Coordination polymer Leptin Adipose tissue 010402 general chemistry 010403 inorganic & nuclear chemistry 01 natural sciences In vitro 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry In vivo Gene expression Materials Chemistry Particle size Physical and Theoretical Chemistry After treatment |
| Zdroj: | Journal of Structural Chemistry. 61:1138-1144 |
| ISSN: | 1573-8779 0022-4766 |
| DOI: | 10.1134/s0022476620070185 |
| Popis: | A new 3-dimensional (3D) Co(II)-based coordination polymer, namely, {[Co(L1)](H2O)}n(H2O) (1) (H2L1 = 3,3′-(pyridine-3,5-diyl) dibenzoic acid), is synthesized under the solvothermal reaction conditions. Furthermore, a green-hand grinding technique is implemented to reduce the particle size of complex 1 to generate nanoscale 1 (denoted as nano-1 hereafter). Furthermore, the biological function of the compound is evaluated on the obesity model and the related mechanism is explored. RT-PCR is performed for the evaluation of the leptin gene expression in adipose cells after treating with the compound. ELISA is conducted to determine the leptin content in adipose tissues in vivo after treatment with the compound. |
| Databáze: | OpenAIRE |
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