Polymeric Particles as Vaccine Delivery Systems
| Autor: | P. Malyala, D.T. O'Hagan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Engineering business.industry medicine.medical_treatment Nanotechnology 02 engineering and technology Vaccine delivery 021001 nanoscience & nanotechnology 03 medical and health sciences 030104 developmental biology Risk analysis (engineering) Vaccine adjuvant New product development medicine Research studies 0210 nano-technology business Adjuvant |
| DOI: | 10.1016/b978-0-12-804019-5.00012-8 |
| Popis: | The landscape of available vaccine adjuvants and delivery systems is expanding significantly from humble beginnings, to now include emulsions, liposomes, and potential others. Several new-generation adjuvant and delivery systems are currently under evaluation in the clinic and in early research studies. Among these alternative approaches, use of synthetic polymeric particles, including those based on poly(lactide-co-glycolide) (PLG), is a technology that has been extensively evaluated over a number of years, including in clinical trials. In this chapter, we will make a critical appraisal of the overall potential of polymeric particles as vaccine delivery systems, and make comparisons with alternative approaches. We will try to assess both the advantages and disadvantages, and compare these systems with competing technologies that may accomplish a similar or better outcome. Since polymeric particles have been available for several decades without advancing significantly toward product development in the vaccine field, it is necessary to highlight the main causes for this lack of advancement. Since PLG microparticles are included in commercial products in the nonvaccine pharmaceutical arena, it has been assumed that the path to vaccine development is relatively clear. Nevertheless, the absence of product development for vaccines despite intensive investigation is a striking contrast, and needs to be explained for a fuller understanding of the real potential of this technology. |
| Databáze: | OpenAIRE |
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