A performance limitation for blood glucose regulation in type 1 diabetes accounting for insulin delivery delays
| Autor: | Carmel E. Smart, Bruce R. King, Adrian M. Medioli, Graham C. Goodwin, Hieu V. Phan, Diego S. Carrasco, Carly Stephen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0209 industrial biotechnology
medicine.medical_specialty Type 1 diabetes business.industry Insulin medicine.medical_treatment Insulin delivery 030209 endocrinology & metabolism 02 engineering and technology medicine.disease 03 medical and health sciences 020901 industrial engineering & automation 0302 clinical medicine Diabetes mellitus medicine Blood sugar regulation Intensive care medicine Insulin injection business Biomedical engineering |
| Zdroj: | CDC |
| DOI: | 10.1109/cdc.2016.7799036 |
| Popis: | The usual recommendation made by clinicians to type 1 diabetics is that they should inject insulin when consuming a meal or, preferably, slightly earlier. However, in practice, insulin injection maybe delayed. In this paper we develop a fundamental limit on performance when insulin is delivered at some time other than the preferred time. The paper develops an optimal injection policy which minimizes the maximum blood glucose response whilst ensuring that the minimum response does not fall below a pre-specified level. The result provides a “gold standard” against which other insulin injection policies can be compared. Implementation issues are also briefly described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|