Synthesis of [18F]-γ-Fluoro-α,β-unsaturated Esters and Ketones via Vinylogous 18F-Fluorination of α-Diazoacetates with [18F]AgF

Autor:	Stephen Thompson, Peter Scott, Melanie S. Sanford, Isaac M. Jackson, Allen F. Brooks, So Jeong Lee, Naoko Ichiishi
Rok vydání:	2019
Předmět:	chemistry.chemical_compound 010405 organic chemistry Chemistry Product (mathematics) Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis Derivative (chemistry) 0104 chemical sciences
Zdroj:	Synthesis. 51:4401-4407
ISSN:	1437-210X 0039-7881
Popis:	This communication reports a method for the vinylogous radiofluorination of α-diazoacetates to generate [18F]-γ-fluoro-α,β-unsaturated esters and ketones in moderate to good radiochemical yields. The method uses no-carrier-added [18F]AgF and is compatible with aromatic and non-aromatic substrates and a number of different functional groups. The labeling method is showcased in the synthesis of a fluorinated cholest-5-en-3-one derivative as well as a difluorinated product pertinent to drug discovery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bbaaad8a8b27754d4a2584623a81f1c5 https://doi.org/10.1055/s-0039-1690012 Zobrazit plný text záznamu