Synthesis of [18F]-γ-Fluoro-α,β-unsaturated Esters and Ketones via Vinylogous 18F-Fluorination of α-Diazoacetates with [18F]AgF
Autor: | Stephen Thompson, Peter Scott, Melanie S. Sanford, Isaac M. Jackson, Allen F. Brooks, So Jeong Lee, Naoko Ichiishi |
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Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Synthesis. 51:4401-4407 |
ISSN: | 1437-210X 0039-7881 |
Popis: | This communication reports a method for the vinylogous radiofluorination of α-diazoacetates to generate [18F]-γ-fluoro-α,β-unsaturated esters and ketones in moderate to good radiochemical yields. The method uses no-carrier-added [18F]AgF and is compatible with aromatic and non-aromatic substrates and a number of different functional groups. The labeling method is showcased in the synthesis of a fluorinated cholest-5-en-3-one derivative as well as a difluorinated product pertinent to drug discovery. |
Databáze: | OpenAIRE |
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