New Iridoid Glycosides with Antidepressant Activity Isolated from Cyperus rotundus
| Autor: | Ya-Mei Yang, Chun-Hong He, Zhong-liu Zhou, Cui-Ping Zhou, Wen-Qing Yin, Hong Guo, Xiao-Na Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Iridoid Glycosides
Traditional medicine biology Chemistry Negundoside General Chemistry General Medicine biology.organism_classification 030226 pharmacology & pharmacy Rhizome 03 medical and health sciences 0302 clinical medicine Cyperus 030220 oncology & carcinogenesis Drug Discovery Antidepressant Motor activity Cyperus rotundus |
| Zdroj: | CHEMICAL & PHARMACEUTICAL BULLETIN. 64:73-77 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Based on bioactive screening results, two new iridoid glycosides, named rotunduside G (1) and rotunduside H (2), were isolated from the rhizomes of Cyperus rotundus, together with four known ones, negundoside (3), nishindaside (4), isooleuropein (5) and neonuezhenide (6). Their structures were elucidated on the basis of spectroscopic methods and from literature values. In mice models of despair, 1 and 2 showed significant antidepressant activity. |
| Databáze: | OpenAIRE |
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