| Popis: |
Publisher Summary This chapter discusses the protein glycosylation in yeast. Glycosylated proteins are found in all eukaryotes, in many archaebacteria, and exceptionally in eubacteria. The glycosylation of proteins is the most complex type of protein modification known in nature. This assumption is strengthened by the observation that the initial rather evolved and complicated reaction sequence responsible for protein N-glycosylation, the dolichol cycle, has been conserved in evolution from yeast to man. Two functional levels have to be distinguished when considering protein glycosylation. A cellular, most likely intracellular, one that corresponds from an evolutionary point of view to the primary function which should be present in all organisms, and secondary functions that have arisen later during evolution; the latter are restricted to higher eukaryotes and obviously are represented by the examples. The ER-located reactions of N-glycosylation are conserved from yeast to man, because they must have been and still must be of importance in any organism. |
