232: Survival Predictors of Severe SARS-CoV-2 Pneumonia in the Intensive Care Unit: Single-Center Study

Autor: Luis E. Colunga Lozano, Mario Alberto Ruiz-Gonzalez
Rok vydání: 2020
Předmět:
Zdroj: Critical Care Medicine. 49:101-101
ISSN: 0090-3493
Popis: INTRODUCTION: In December 2019, an outbreak of a new strain of coronavirus (Covid-19) was registered Currently, COVID-19 has affected 213 countries around the world, with approximately 6, 097,160 active cases, from which, 1% are serious or critical (1%) Several studies have reported the mortality in patients admitted to the intensive care unit (ICU), which ranges from 25% to 62% Mortality predictors have been identified, as male gender, elderly patients, comorbidities (e g Diabetes Mellitus) and organ dysfunction development (e g acute kidney injury, acute distress respiratory syndrome), however, few information has been reported form Latin-American countries We aim to explore the survival predictors for severe SARS-CoV2 pneumonia patients admitted to our ICU METHODS: We performed a retrospective cohort study from June to July 2020 We included all the patients admitted into the ICU at the Hospital Civil De Guadalajara ?Dr Juan I Menchaca? in Guadalajara Mexico Patients were confirmed or suspected with severe COVID-19 pneumonia All the participant's characteristics and outcomes were adjudicated from the patients' charts We performed a univariate Cox regression analysis RESULTS: We included 64 patients, the median age was 57 years (range 25-75 years) and 44 patients (68 8%) were men At analysis seven patients continue to be treated at the ICU Seventeen (26 5%) patients were discharge home, four patients (6 25%) died after ICU discharge and thirtysix (56 2%) died in the ICU In univariate Cox regression analysis, we identified the following predictors related to patient mortality: Age per year (Hazard ratio [HR] 0 95 95% CI 0 92 - 0 99), female gender (HR 0 39 95% CI 0 16 - 0 91), absence of acute kidney injury (AKI) at ICU admission (HR 0 23 95% CI 0 07 - 0 70), absence of ARDS (HR 0 14 95% CI 0 04-0 41), absence of hemodynamic instability (HR 0 29 95% CI 0 10 - 0 81) APACHE II (HR 0 95 95% CI 0 89 - 1 01) shown a trend, however, no statistical difference was found CONCLUSIONS: Younger age, female gender and lack of organ dysfunctions were related to patient's survival Our study results are similar to the reported in the literature, however, our sample size was small We will continue our recruitment and complete the follow-up to improve the statistical performance of our model
Databáze: OpenAIRE
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