Immunomodulatory activity of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed in rat
| Autor: | Mahabaleshwar V. Hegde, Anand A. Zanwar, Santosh T Devkar, Keshav K. Deshmukh, Deepak M. Kasote |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.drug_class
Butanol Ether Fraction (chemistry) Pharmacology Biochemistry Genetics and Molecular Biology (miscellaneous) Immunostimulant chemistry.chemical_compound Immune system chemistry Biochemistry n-Butanol embryonic structures Humoral immunity cardiovascular system medicine Phenols circulatory and respiratory physiology |
| Zdroj: | Asian Pacific Journal of Tropical Biomedicine. 2:S623-S626 |
| ISSN: | 2221-1691 |
| DOI: | 10.1016/s2221-1691(12)60285-8 |
| Popis: | Objective To investigate the immunomodulatory activity of ether insoluble phenolic components of n -butanol fraction (EPC-BF) of flaxseed in rat. Methods Immunomodulatory activity of EPC-BF was assessed in rat at oral doses of 150 and 300 mg/kg using neutrophil adhesion test, heamagglutination test and measuring delayed type hypersensitivity response. Results EPC-BF modulates immune response by significantly reducing cell-mediated immune response at oral dose 150 mg/kg but not at dose 300 mg/kg. However, EPC-BF did not affect on the neutrophil adhesion and humoral immunity at both the studied doses. Conclusion EPC-PC modulates immune response by reducing cell-mediated immune response at lower dose but not at higher dose, which could be due to the presence of both immunostimulant and immunosuppressant phenols together in EPC-BF. These studies suggest that EPC-BF could be a promising source for new immune modifier. |
| Databáze: | OpenAIRE |
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