Further observations on the rhodium (I)-catalysed tandem hydrosilylation-intramolecular aldol reaction

Autor:	Marta Freiria, Andrew J. Whitehead, William B. Motherwell, Derek A. Tocher
Rok vydání:	2004
Předmět:	Hydrosilylation Organic Chemistry chemistry.chemical_element Biochemistry Combinatorial chemistry Catalysis Rhodium chemistry.chemical_compound chemistry Aldol reaction Intramolecular force Drug Discovery Michael reaction Stereoselectivity Baylis–Hillman reaction
Zdroj:	Tetrahedron. 60:2673-2692
ISSN:	0040-4020
DOI:	10.1016/j.tet.2003.12.057
Popis:	The rhodium (I) catalysed tandem hydrosilylation-intramolecular aldol reaction provides a simple strategy for construction of a range of usefully functionalised five-membered rings from readily prepared 6-oxo-2-hexenoates in good yield and with good to excellent stereoselectivity. A series of silanes and rhodium catalysts have been investigated. Stereoselectivity proved to be highly dependant on the catalyst as well as on the substitution pattern of the parent substrate. The extension of this methodology for the synthesis of larger ring sizes has also been evaluated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bb94a6fe1342a7ec63d2b34b8165d15c https://doi.org/10.1016/j.tet.2003.12.057 Zobrazit plný text záznamu Full Text from ScienceDirect