Effects of inactivity on myosin heavy chain composition and size of rat soleus fibers
| Autor: | V. Reggie Edgerton, Robert J. Talmadge, Hui Zhong, Elena J. Grossman, Roland R. Roy |
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| Rok vydání: | 1998 |
| Předmět: |
Soleus muscle
medicine.medical_specialty CATS Physiology Skeletal muscle chemical and pharmacologic phenomena Anatomy Biology medicine.disease Major histocompatibility complex Spinal cord Cellular and Molecular Neuroscience Endocrinology Atrophy medicine.anatomical_structure Physiology (medical) Internal medicine Myosin medicine biology.protein Composition (visual arts) Neurology (clinical) |
| Zdroj: | Muscle & Nerve. 21:375-389 |
| ISSN: | 1097-4598 0148-639X |
| DOI: | 10.1002/(sici)1097-4598(199803)21:3<375::aid-mus12>3.0.co;2-z |
| Popis: | Myosin heavy chain (MHC) and fiber size properties of the adult rat soleus were determined after 4-60 days of complete inactivity, i.e., lumbar spinal cord isolation. Soleus atrophy was rapid and progressive, i.e., 25% and 64% decrease in weight and 33% and 75% decrease in fiber size after 4 and 60 days of inactivity, respectively. Changes in MHC occurred at a slower rate than the atrophic response. After 15 days there was de novo expression of type IIx MHC (approximately 10%). By 60 days, type IIx MHC accounted for 33% of the total MHC content, and 7% of the fibers contained only type IIx MHC. The relative amount of type I MHC was reduced from 93% in control to 49% after 60 days of inactivity. Therefore, the effects of 60 days of inactivity suggest that during this time period at least 75% of fiber size and approximately 40% of type I MHC composition of the adult rat soleus can be attributed to activation-related events. |
| Databáze: | OpenAIRE |
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