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The multifunctional nanocompoties (MFNCs) as drug release carriers are prepared by cross-linking reaction of cationic chitosan (CS) and anionic tripolyphosphate (TPP) to encapsulate Fe3O4 nanoparticles(NPs) loaded cancer therapeutic agents such as berberine (BB), KCY-24B, KCY-Tai…etc were studied. These MFNCs were characterized by fourier transform infrared spectrophotometer (FT-IR), ultra violet–visible-near infrared spectrophotometer (UV-VIS-NIR spectrophotometer), size analysis, transmission electron microscope (TEM) and field-emission scanning electron microscope (FESEM). Then we obtained here the preparation method, characterization, and capability of these efficative nanoparticles. Cell celluar uptake and distribution of MFNCs were also inspected in human colon adenocarcinoma cell lines (Colo 205). |
