Anticonvulsant activity of a new 1,4-benzodiazepine in rodents and the baboonPapio papio
| Autor: | B. S. Meldrum, David C. Piper, Colin R. Gardner |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Benzodiazepine biology business.industry medicine.drug_class musculoskeletal neural and ocular physiology medicine.medical_treatment Pharmacology Clonazepam Anticonvulsant Endocrinology biology.animal Internal medicine Sedative Drug Discovery medicine Potency business Baboon medicine.drug |
| Zdroj: | Drug Development Research. 1:77-82 |
| ISSN: | 1098-2299 0272-4391 |
| Popis: | RU 31124, a new anticonvulsant 1,4-benzodiazepine was compared with clonazepam in a series of tests in rats and mice. It demonstrated greater anticonvulsant potency whilst having equivalent sedative properties to clonazepam. This profile of activity was confirmed in the photosensitive baboon, Papio papio, in which RU 31124 provided long-lasting protection against convulsions at doses having little or no sedative side effects. |
| Databáze: | OpenAIRE |
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