Sessile serrated adenoma/polyp showed rapid malignant transformation in the final 13 months
| Autor: | Eri Tamura, Yasushi Adachi, Makoto Eizuka, Yuko Yoshida, Sadahiro Amemori, Eiichiro Yamamoto, Yoshihito Tanaka, Hiro-o Matsushita, Hiromu Suzuki, Kenjiro Yoshikawa, Kazunori Tsuda, Tamotsu Sugai, Hiro-o Yamano, Eiji Harada, Ryo Takagi, Bunichiro Kato, Hiroshi Nakase |
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| Rok vydání: | 2019 |
| Předmět: |
business.industry
Magnifying endoscopy Gastroenterology Microsatellite instability medicine.disease Sessile serrated adenoma/polyp Advanced cancer digestive system diseases Malignant transformation 03 medical and health sciences 0302 clinical medicine CpG site 030220 oncology & carcinogenesis medicine Cancer research 030211 gastroenterology & hepatology Radiology Nuclear Medicine and imaging business Sessile serrated adenoma |
| Zdroj: | Digestive Endoscopy. 32:979-983 |
| ISSN: | 1443-1661 0915-5635 |
| DOI: | 10.1111/den.13572 |
| Popis: | Based on the concept of the adenoma-carcinoma sequence, most colorectal cancers are considered to arise from conventional adenomas. However, recent studies suggested that a subset of colorectal cancers develop through the serrated neoplastic pathway. It has also been documented that serrated polyps can rapidly transform into invasive cancers even when they are small in size. We now describe a case of a sessile serrated adenoma/polyp which had been followed up for 4 years but eventually showed rapid transformation into an advanced cancer accompanied by a remarkable morphological change within only 13 months. Retrospective genetic and epigenetic analyses showed microsatellite instability, CpG island methylator phenotype-positive, and BRAF mutation in the lesion, suggesting the tumor had developed through the serrated neoplastic pathway. This case may provide valuable information about the natural history of sessile serrated adenoma/polyps which eventually progress to advanced cancers. |
| Databáze: | OpenAIRE |
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