Alterations in the Fungal Microbiome in Ulcerative Colitis
| Autor: | Katie Hsia, Naisi Zhao, Mei Chung, Khalid Algarrahi, Laleh Montaser Kouhsari, May Fu, Hannah Chen, Siddharth Singh, Dominique S Michaud, Sushrut Jangi |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Inflammatory Bowel Diseases. |
| ISSN: | 1536-4844 1078-0998 |
| Popis: | Background Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis. Methods We analyzed data from the SPARC IBD (Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease) registry. We evaluated the fungal composition of fecal samples from 98 patients with ulcerative colitis across endoscopic activity (n = 43), endohistologic activity (n = 41), and biologic exposure (n = 82). Across all subgroups, we assessed fungal diversity and differential abundance of taxonomic groups. Results We identified 500 unique fungal amplicon sequence variants across the cohort of 82 patients, dominated by phylum Ascomycota. Compared with endoscopic remission, patients with endoscopic activity had increased Saccharomyces (log2 fold change = 4.54; adjusted P Conclusions Endoscopic inflammation in ulcerative colitis is associated with an expansion of Saccharomyces and Candida compared with remission. The role of these fungal taxa as potential biomarkers and targets for personalized approaches to therapeutics in ulcerative colitis should be evaluated. |
| Databáze: | OpenAIRE |
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