Compatibility of Bricef Dry Syrup with Mixed Solutions
| Autor: | Kikuo Yamazoe, Shigeo Kachi, Itsuro Kawakage, Mikio Nishikawa, Junichi Nihashi, Kiichiro Fujii, Yuzuru Ito |
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| Rok vydání: | 1981 |
| Předmět: | |
| Zdroj: | Japanese Journal of Hospital Pharmacy. 7:308-313 |
| ISSN: | 2185-9477 0389-9098 |
| DOI: | 10.5649/jjphcs1975.7.308 |
| Popis: | Compatibilty of Bricef Dry Syrup (cefatrizine oral suspension) with mixed solutions which were often pre scribed in our hospital was investigated in terms of changes in external appearance pH and residual potency of cefatrizine (CFT). These changes were checked immediately after and 1, 3, 5, 7 and 14 days after mixing. The results showed lowering, to some extent, of CFT potency in relatively high pH region. Especially, when dry syrup was mxed with an alkaline solution, CFT potency reduced significantly within 24 hours at room temperature. These results suggest that careful attention should be paid to the above combination since a risk of incompatibility may be involved.Color of suspensions of a few preparations changed during the storage. The change in color should be avoided to prevent anxiety in patients, though its correlation with stability of CFT is not clear. In combiantions with other solutions, the change in appearance, pH and potency of CFT was small, suggesting that such combinations be clinically recommendable. |
| Databáze: | OpenAIRE |
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