Evaluation of the Mammary Tumor Inhibiting Properties
| Autor: | Ronald Gust, Thilo Spruss, Richard Müller, Sabine Schertl, Helmut Schönenberger |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cisplatin
medicine.medical_specialty Mammary tumor DNA synthesis Ratón medicine.drug_class Mammary gland Pharmaceutical Science Biology medicine.disease Endocrinology medicine.anatomical_structure Mechanism of action Estrogen Internal medicine Drug Discovery medicine Cancer research Carcinoma medicine.symptom medicine.drug |
| Zdroj: | Archiv der Pharmazie. 325:113-118 |
| ISSN: | 1521-4184 0365-6233 |
| DOI: | 10.1002/ardp.19923250211 |
| Popis: | Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes produce a strong configuration-dependent inhibition of the hormone sensitive MXT-mammary carcinoma of the mouse. Besides an interference in DNA synthesis analogous to that of cisplatin, an estrogen level lowering effect is responsible for its antitumor activity. The new complexes also show a significant activity on the hormone-independent MXT-mammary carcinoma of the mouse. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text