Laboratory tests of the horse strangles vaccine
| Autor: | E. I. Elbyadova, N. P. Tarabukina, S. G. Petrova, M. P. Neustroev |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | IOP Conference Series: Earth and Environmental Science. 604:012002 |
| ISSN: | 1755-1315 1755-1307 |
| DOI: | 10.1088/1755-1315/604/1/012002 |
| Popis: | An inactivated vaccine against horse strangles was developed based on the Streptococcus equi strain “N-5/1”, which has sufficient efficacy and environmental safety. The vaccine was tested in accordance with the order of the Ministry of Agriculture of the Russian Federation No. 101 dated March 6, 2018 “On approval of the rules for preclinical studies of a medicinal product for veterinary use, clinical study of a medicinal product for veterinary use, and bioequivalence of a medicinal product for veterinary use”. According to the results of the tests, the absence of toxicity and irritating activity during intragastric administration of the vaccine to white mice at the maximum permissible dose (1 cm3) was established. The vaccine withstands the test for pyrogenicity, does not cause an increase or decrease in body temperature in animals during the observation period. A sufficiently high immunogenicity in laboratory animals of an inactivated vaccine was determined with a single injection (up to 80%), which meets the general requirements for the immunogenicity of microorganism strains in the composition of inactivated vaccines. |
| Databáze: | OpenAIRE |
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