New natural coumarins from Trichocline macrocephala (Asteraceae)
| Autor: | Miriam Anders Apel, Mara Rejane Ritter, Gilsane Lino von Poser, Krissie D. Soares, Isabel C. Gouvêa de Borba, Henrique Bridi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Folk medicine
Trichocline macrocephala biology Traditional medicine 010405 organic chemistry Plant Science Respiratory tract disease Asteraceae biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 32:129-133 |
| ISSN: | 1874-3900 |
| Popis: | The xylopodium of Trichocline macrocephala Less. is used in folk medicine in the extreme northeast region of Rio Grande do Sul state, Brazil, to treat respiratory tract disorders. This study reports the isolation and elucidation of two undescribed compounds, named 7-methoxy-glaupalol and 8-hydroxy-isogerberacoumarin, along with glaupalol, 5-methoxycoumarin, 5,6-dimethoxycoumarin and 7-methoxycoumarin. Their structures were determined by application of 1D and 2D NMR techniques and HRESIMS analysis. The 5-methylcoumarin glaupalol exhibited antichemotactic activity on leukocytes migration at concentrations from 0.01 to 5 μg/mL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect