The Changes of Expression Levels in Mir-181a and Mir-30d, and a Significant Correlation between Clinical Patient Data
| Autor: | Shima Hojabri Mahani, Reza Mahmanzar, Faryad Sharifian, Fatemeh Jabari, Mojtaba Mohammadnejad pahmadani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
business.industry Colorectal cancer Energy Engineering and Power Technology Cancer Disease medicine.disease Correlation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Fuel Technology 030220 oncology & carcinogenesis Complementary DNA microRNA Cancer research Medicine Cancer biomarkers RNA extraction business |
| Zdroj: | Cancer and Clinical Oncology. 8:16 |
| ISSN: | 1927-4866 1927-4858 |
| Popis: | Purpose: Colorectal cancer is known as the most common gastrointestinal cancers. As the age increases, the risk for this cancer also increases, so the only way to improve and hope for life in these patients is early diagnosis of the disease. So far, numerous molecular studies have been carried out on microRNAs in colorectal cancer. In addition, since some of them can be identified as cancer biomarkers. Therefore, in this study we have investigated the expression level of Mir-30d and Mir-181a as cancer biomarkers. Method: The changes of Mir-30d and Mir-181a expression levels in 60 colorectal tumor tissues and 60 adjacent tumor tissues, after RNA extraction and cDNA synthesis were surveyed using the Real Time-PCR method. Results: The results have reported a considerable reduction in the expression level of Mir-30d in tumor tissues, as well as a significant increase in the expression level of Mir-181a tumor expression in tumor tissues (P0.05). |
| Databáze: | OpenAIRE |
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