Synthesis, characterization, antibacterial and antiproliferative activities of monodisperse chitosan- based silver nanoparticles

Autor:	Dien Gia Pham, Hoang Vinh Tran, Cham Thi Ba, Hoang Dinh Vu, Thinh Ngoc Nguyen, Phuc Xuan Nguyen, Lam Dai Tran
Rok vydání:	2010
Předmět:	biology Chemistry Lactobacillus fermentum biology.organism_classification medicine.disease_cause Silver nanoparticle Chitosan chemistry.chemical_compound Colloid and Surface Chemistry Biochemistry Staphylococcus aureus medicine Candida albicans Escherichia coli Bacteria Antibacterial agent
Zdroj:	Colloids and Surfaces A: Physicochemical and Engineering Aspects. 360:32-40
ISSN:	0927-7757
Popis:	Silver nanoparticles (AgNPs) have been known to have inhibitory and bactericidal effects. In this paper we investigated: (i) the synthesis and kinetics of finely dispersed AgNPs in a biocompatible chitosan-derived polysaccharide solution; (ii) the antibacterial activities toward both gram− ( Escherichia coli and Pseudomonas aeruginosa ) and gram+ bacteria ( Lactobacillus fermentum , Staphylococcus aureus and Baciilus subtilis ) and yeast ( Candida albicans ) of the obtained AgNPs; and (iii) in vitro cytotoxicity against HepG2 (hepatocellular carcinoma), Lu (human lung carcinoma), KB (human epidermic carcinoma), MCF-7 (human breast carcinoma) cancer cell lines. The samples demonstrated considerably high antibacterial and antiproliferative activities against above bacterial strains and cell lines, which can be explained on the basis of finely and homogenously dispersed nanoparticles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bb418a3efdb4557fdad06fa4769c9400 https://doi.org/10.1016/j.colsurfa.2010.02.007 Zobrazit plný text záznamu Full Text from ScienceDirect