The search for new antigenic targets in myasthenia gravis

Autor:	Angela Vincent, David Beeson, Judith Cossins, Inga Koneczny, Susan Maxwell, Patrick Waters, Maria Isabel Leite, Katarzyna Marta Zoltowska, Katsiaryna Belaya, Leslie Jacobson
Rok vydání:	2012
Předmět:	Agrin biology General Neuroscience Autoantibody Transfection medicine.disease Virology General Biochemistry Genetics and Molecular Biology Myasthenia gravis History and Philosophy of Science Antigen Immunology biology.protein medicine Antibody Tyrosine kinase Acetylcholine receptor
Zdroj:	Annals of the New York Academy of Sciences. 1275:123-128
ISSN:	0077-8923
Popis:	Around 80% of myasthenia gravis patients have antibodies against the acetylcholine receptor, and 0-60% of the remaining patients have antibodies against the muscle-specific tyrosine kinase, MuSK. Another recently identified antigen is low-density lipoprotein receptor-related protein 4 (Lrp4). To improve the existing assays and widen the search for new antigenic targets, we have employed cell-based assays in which candidate target proteins are expressed on the cell surface of transfected cells and probed with patient sera. These assays, combined with use of myotube cultures to explore the effects of the antibodies, enable us to begin to identify new antigenic targets and test antibody pathogenicity in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bb410b7acac3d92fdbbb5191b903280e https://doi.org/10.1111/j.1749-6632.2012.06833.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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