New Fluorine-Containing Derivatives of 4-Anilino-2-(methylsulfanyl)quinazolines

Autor:	V. N. Charushin, Galina N. Lipunova, Emiliya V. Nosova, Yu. V. Permyakova
Rok vydání:	2021
Předmět:	Minimum inhibitory concentration chemistry.chemical_compound 010405 organic chemistry Chemistry Organic Chemistry Quinazoline Fluorine containing 01 natural sciences Medicinal chemistry 0104 chemical sciences
Zdroj:	Russian Journal of Organic Chemistry. 57:479-482
ISSN:	1608-3393 1070-4280
Popis:	A number of new 4-anilinoquinazolines were synthesized starting from 6,7,8-trifluoro-2-(methyl­sulfanyl)quinazolin-4(3H)-one. Reactions of the title compounds with cyclic secondary amines involved substitu­tion of the 7-fluorine atom with retention of the methylsulfanyl group on C2. 6,7,8-Trifluoro-4-(2-me­thoxyanilno)-2-(methylsulfanyl)quinazoline showed in vitro tuberculostatic activity with a minimum inhibitory concentration of 1.5 μg/mL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bb33942f1317c4712fd120aa8c241224 https://doi.org/10.1134/s1070428021030222 Zobrazit plný text záznamu Plný text ve formátu PDF