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Background: Role of ivabradine in patients with anterior wall ST-elevation myocardial infarction (STEMI) is unknown. Methods: This is a two-center, randomized controlled, double-blinded trial, that included patients presenting with anterior wall STEMI and eligible for primary percutaneous coronary intervention (PPCI) from June 2016 through July 2018. After PPCI, patients were randomized (1:1) to receive bisoprolol plus ivabradine (ivabradine group) versus bisoprolol plus placebo (control group). Up-titration of ivabradine and/or bisoprolol was performed over a period of 6 weeks in all patients as tolerated. The primary outcome was resting heart rate at 6 weeks. Other secondary clinical outcomes were studied. Results: A total of 670 patients were included. Ivabradine was associated with a significant reduction in heart rate compared to placebo at 2 weeks (73.0 ± 2.8 vs 78.2 ± 1.75 bpm, respectively, p |
