Increased identification of novel variants in type 2 diabetes, birth weight and their pleiotropic loci

Autor:	Wei-Min Deng, Jonathan Greenbaum, Cheng Peng, You-Ping Chen, Hong-Wen Deng, Xu Lin, Xia-Fang Wang, Chun-Ping Zeng, Yuan-Cheng Chen, Rou Zhou, Jie Shen
Rok vydání:	2017
Předmět:	0301 basic medicine False discovery rate Genetics endocrine system diseases Endocrinology Diabetes and Metabolism nutritional and metabolic diseases Single-nucleotide polymorphism Genome-wide association study Type 2 diabetes Biology Heritability medicine.disease Phenotype 03 medical and health sciences 030104 developmental biology Pleiotropy medicine CDKAL1
Zdroj:	Journal of Diabetes. 9:898-907
ISSN:	1753-0393
Popis:	Background Clinical and epidemiological findings point to an association between type 2 diabetes (T2D) and low birth weight (BW). However, the nature underlying their relationship is largely unknown. Here, we aim to identify novel single-nucleotide polymorphisms (SNPs) in T2D, BW and their pleiotropic loci. Methods We applied a pleiotropy-informed conditional false discovery rate (cFDR) method to two independent GWAS summary statistics of T2D (n = 149,821) and BW (n = 26,836). Results Conditional Q-Q plot shows a strong enrichment of genetic variants in T2D conditioned on different levels of association with BW. We identified 133 SNPs with a significance threshold of cFDR
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bb27cde0b3eebd63e53632cbd88e173b https://doi.org/10.1111/1753-0407.12510 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.