Longitudinal resting state fMRI analysis in healthy controls and premanifest Huntington's disease gene carriers: A three-year follow-up study
| Autor: | Annette A. van den Berg-Huysmans, Eve M. Dumas, Raymund A.C. Roos, Serge A.R.B. Rombouts, Jeroen van der Grond, Simon J.A. van den Bogaard, Omar F. F. Odish, Ellen P. Hart |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Movement disorders Radiological and Ultrasound Technology Resting state fMRI Gene carrier Functional connectivity Disease medicine.disease Physical medicine and rehabilitation Neurology Huntington's disease Region of interest Cohort medicine Radiology Nuclear Medicine and imaging Neurology (clinical) Anatomy medicine.symptom Psychology Neuroscience |
| Zdroj: | Human Brain Mapping |
| ISSN: | 1065-9471 |
| DOI: | 10.1002/hbm.22616 |
| Popis: | Background: We previously demonstrated that in the premanifest stage of Huntington's disease (preHD), a reduced functional connectivity exists compared to healthy controls. In the current study, we look at possible changes in functional connectivity occurring longitudinally over a period of 3 years, with the aim of assessing the potential usefulness of this technique as a biomarker for disease progression in preHD. Methods: Twenty-two preHD and 17 healthy control subjects completed resting state functional magnetic resonance imaging (fMRI) scans in two visits with 3 years in between. Differences in resting state connectivity were examined for eight networks of interest using FSL with three different analysis types: a dual regression method, region of interest approach, and an independent component analysis. To evaluate a possible combined effect of gray matter volume change and the change in blood oxygenation level dependent signal, the analysis was performed with and without voxel-wise correction for gray matter volume. To evaluate possible correlations between functional connectivity change and the predicted time to disease onset, the preHD group was classed as preHD-A if ≥10.9 years and preHD-B if |
| Databáze: | OpenAIRE |
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