Synthesis and biological properties of new naltrexone-peptide hybrids
| Autor: | M. Pachocka, Gavril W. Pasternak, S.W. Gumulka, K. Misterek, Andrzej W. Lipkowski |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Semicarbazides Physiology Stereochemistry Clinical Biochemistry Peptide Biological activity Biochemistry Naltrexone Benzomorphan δ-opioid receptor Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Opioid chemistry medicine Opioid peptide medicine.drug |
| Zdroj: | Regulatory Peptides. 53:S127-S128 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/0167-0115(94)90274-7 |
| Popis: | Hybridization of benzomorphan alkaloids with opioid peptide «addresses» is one of the successful method of modulation of receptor selectivity and affinity of opioid ligands. In this paper we present biological properties of two new compounds, hybridized naltrexone with Leu-D-Phe-NHNH 2 or BrAc-Leu-D-Phe-NHNH 2 . These semicarbazides express significant increase in affinity to delta receptors |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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