The use of mini pigs ? A new kind of experimental animal ? To study the embryotropic action of phenazepam

Autor:	A. N. Yavorskii, Strekalova Sn, Smol'nikova Nm, V. A. Dushkin, S. S. Boiko, P. R. Poznakhirev, B. I. Lyubimov
Rok vydání:	1979
Předmět:	Blood level Experimental animal Animal science Phenazepam medicine Physiology General Medicine Biology General Biochemistry Genetics and Molecular Biology Breed medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 88:1290-1292
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00835575
Popis:	Experiments on a Siberian breed of mini pigs showed that phenazepam, in a dose of 1 mg/kg internally throughout the period of organogenesis, has neither embryotoxic nor teratogenic action. Parallel determinations of the blood level of the compound were made in pregnant animals. It can be concluded from the results of this investigation that mini pigs are a promising species with which to test the embryotropic activity of drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bb15c4201bda853e995a00a0e8bdcca7 https://doi.org/10.1007/bf00835575 Zobrazit plný text záznamu Full text from SpringerLink