Coinfection: influenza A virus and Aspergillus fumigatus
| Autor: | Meagan D. Rippee-Brooks, Christopher R. Lupfer |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 200:52.28-52.28 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Bacterial coinfections with influenza A virus (IVA) are extremely serious and life-threatening. However, there exists limited data gathered about the importance of fungal infections with IAV. Clinical case reports indicate that fungal coinfections do happen and suggest the pandemic 2009 IAV has a propensity to predispose patients to secondary fungal infections more than previous IAV strains. However, the factors involved remain to be determined. We have developed an in vitro model using primary mouse bone marrow derived macrophages infected with IVA and coinfected with the opportunistic fungal pathogen Aspergillus fumigatus. Our results indicate that IVA and fungal coinfections synergistically enhance cell signaling and cytokine production. We propose this exacerbated immune response during IVA and A. fumigatus predisposes clinical patients to more severe pneumonia, and we seek to identify the pathways responsible for the heightened cytokine responses and their significance in vivo. |
| Databáze: | OpenAIRE |
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