Amplifying Effects of Several Vasoconstrictor Agents of αi-Adrenoceptor-Mediated Contraction of Isolated Thoracic Aortae of the Guinea Pig
| Autor: | G.J. Molderings, H.-J. Schümann |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pharmacology
Aorta medicine.medical_specialty Contraction (grammar) General Medicine Biology Ouabain chemistry.chemical_compound Endocrinology chemistry Anesthesia medicine.artery Internal medicine medicine Arachidonic acid Vasoconstrictor Agents medicine.symptom Phenylephrine Vasoconstriction Muscle contraction medicine.drug |
| Zdroj: | Pharmacology. 39:373-382 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000138625 |
| Popis: | In guinea-pig aorta phenylephrine and noradrenaline induced concentration-dependent contractions when beta-adrenoceptors were blocked. The contractile response to phenylephrine was amplified by previous application of subthreshold concentrations of 5-hydroxytryptamine, ouabain, B-HT 920, Bay K 8644, phorbol-12-myristate-13-acetate and arachidonic acid. Bay K 8644 also enhanced the contractile response to noradrenaline. The amplification was not substantially altered by removing the endothelium of the aorta. The increase in cytosolic calcium availability induced by the vasoconstrictor agents investigated may be responsible for the enhancement of the alpha 1-adrenoceptor-mediated contractions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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