INTRACELLULAR MECHANISMS OF TUMOR CELL IMMUNORESISTANCE
| Autor: | Dariusz Pawlak, Beata Sieklucka, Justyna Magdalena Hermanowicz, Krzysztof Nosek |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Chemistry 030302 biochemistry & molecular biology chemical and pharmacologic phenomena Tumor cells General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Immune system Intracellular signaling pathways Cancer cell Cancer research Receptor CD80 Function (biology) Intracellular |
| Zdroj: | Acta Biochimica Polonica. |
| ISSN: | 1734-154X 0001-527X |
| Popis: | One of the main mechanisms for avoiding immune response by cancer cells is by inducing an immunosuppressive environment in the tumor, following the activation of immune checkpoints i.e. PD-1 or CTLA-4 receptor inhibitors on T lymphocytes. Inhibiting the interaction between PD-1 or CTLA-4 and their ligands (PD-L1, CD80, and CD85) leads to unblocking T-lymphocyte function, and thus destroying cancer cells. Certain intracellular signaling pathways are also involved in the development of tumor cell immunoresistance. Blocking the activation of immunosuppressive pathways may increase immunological anti-tumor control |
| Databáze: | OpenAIRE |
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