Blood pressure changes following combined administration of vasoactive drugs with similar effects

Autor:	Tkachenko Bi, M. V. Lioznov
Rok vydání:	1990
Předmět:	biology Chemistry Effector General Medicine Absorption (skin) Pharmacology Phenotype General Biochemistry Genetics and Molecular Biology Cell biology CTL In vivo MHC class I biology.protein Macrophage Secretion
Zdroj:	Bulletin of Experimental Biology and Medicine. 109:278-280
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00839635
Popis:	The in vivo induced pCTL-2 with phenotype L3T4- Lyt2- specific to the H-2Kb molecule, turn into effector CTL during 4 days in the mixed lymphocyte culture (with heat-treated donor stimulators) much more efficiently when donor and recipient are different from one another not only in MHC class I (anti-BIO, MBR BIO.AKM) but in I + II (Kb + Ib) ahti-C57BL/6 BIAD2(RIOI). The initial pCTL-2 differentiation in enhanced as a result of synergistic effect between the Kb alloantigen and rIL2. The anti-Kb pCTL-2, being separated from helper T cells by means of absorption onto the macrophage donor monolayer and elution from it, give rise to pronounced differentiation in simplified conditions, irrespective of the stimulator presence and without external rIL2. It is supposed that these phenomena are raised to secretion of the CTL differentiation factor by the eluted pCTL-2 themselves, and besides, rIL2 may promote for secretion of this factor additionally.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::baec569b17e024c16dcfb7f2c4305118 https://doi.org/10.1007/bf00839635 Zobrazit plný text záznamu Full text from SpringerLink