Antibiotic-Modifying Activity and Chemical Profile of the Essential Oil from the Leaves ofCordia verbenaceaDC
| Autor: | Victoria Regina de Alencar Carvalho, José Galberto Martins da Costa, Maria Karollyna do Nascimento Silva, José J. S. Aguiar, Henrique Douglas Melo Coutinho, Jaime Ribeiro-Filho, Vanessa de Carvalho Nilo Bitu, Edinardo F.F. Matias, Antonio Ivanildo Pinho |
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| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry medicine.drug_class Organic Chemistry Antibiotics Sabinene biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry law.invention Cordia verbenacea 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Germacrene chemistry law Botany medicine Contact method Food science Antibacterial activity Essential oil Bacteria |
| Zdroj: | Journal of Essential Oil Bearing Plants. 20:337-345 |
| ISSN: | 0976-5026 0972-060X |
| DOI: | 10.1080/0972060x.2017.1301220 |
| Popis: | This study aimed to determine the chemical profile of the essential oil obtained from the leaves of C. verbenacea DC and to evaluate its antibiotic and antibiotic-modifying activity by the gaseous contact method of the essential oil and its major component. The essential oil was analyzed by GC-MS. Chemical analysis identified a predominance of sabinene (31.99%), β-caryophyllene (13.10%), bicyclogermacrene (11.06%), germacrene-D (7.44%) and (+) spathulenol (6.53%). The essential oil and sabinene exhibited no antibacterial activity according to the method used. Sabinene combined with all antibiotics showed synergism against S. aureus and the essential oil showed indifference when combined with aminoglycosides. We demonstrated that sabinene has statistically significant antibiotic-modifying activity against S. aureus, indicating this compound as a new alternative pharmaceutical source in fighting infections by Gram-positive bacteria. |
| Databáze: | OpenAIRE |
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