Macrophage migration inhibitory factor (MIF): Its role in the genesis and progression of colorectal cancer
| Autor: | Ana P. García-García, Tonathiu Rodríguez, Miriam Rodriguez-Sosa, Imelda Juárez-Avelar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemokine
biology business.industry Angiogenesis Colorectal cancer animal diseases medicine.medical_treatment Cancer chemical and pharmacologic phenomena respiratory system medicine.disease biological factors Metastasis Cytokine Cancer cell otorhinolaryngologic diseases Cancer research biology.protein Medicine Macrophage migration inhibitory factor business |
| DOI: | 10.1016/b978-0-12-822028-3.00012-1 |
| Popis: | Macrophage migration inhibitory factor (MIF) is a pleiotropic protein with cytokine and chemokine properties that regulate a diverse range of physiological functions related to innate immunity, inflammation, and glucocorticoid-mediated immunosuppression and is highly expressed by cancer cells, via which it affects angiogenesis, tumor growth, and metastasis. The role of MIF in colorectal cancer (CRC) is underscored by data showing that its overexpression in the chronic stages of CRC is associated with clinical severity. The specific functions of MIF are now being defined in CRC, and MIF-targeted biologic therapeutics are in early-stage trials. In this chapter, we summarize current knowledge about the role of MIF in cancer with special emphasis on CRC. |
| Databáze: | OpenAIRE |
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