Thermoanalytical study of cyclocondensation of some derivatives of nitrosouracil

Autor:	Tat'ána Gondová, Peter Králik, Jozef Gonda, Radislav Domanský
Rok vydání:	1997
Předmět:	Steric effects Reaction centre Exothermic reaction chemistry.chemical_compound Chemistry Phase (matter) Substituent Organic chemistry Physical and Theoretical Chemistry Condensed Matter Physics Instrumentation Medicinal chemistry Electronic properties
Zdroj:	Thermochimica Acta. 297:63-69
ISSN:	0040-6031
DOI:	10.1016/s0040-6031(97)00167-6
Popis:	The exothermic conversion of 1,3-dimethyl-4-alkylamino-5-nitrosouracils into theophylline or its 8-substituted derivatives was investigated. The conversion was carried out in the solid phase. The course of this reaction is affected by steric and electronic properties of the substituents present in proximity to the reaction centre of the starting substance. The values of molar reaction enthalpies ( ΔH r ) of 19 derivatives of 1,3-dimethyl-4-alkylamino-5-nitrosouracils were determined. The relationship between these values and the structure of the substituent was examined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::badc48bee36d27c663264e0ade0803dc https://doi.org/10.1016/s0040-6031(97)00167-6 Zobrazit plný text záznamu Full Text from ScienceDirect