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Previously, we have synthesized a 53-peptide containing Cys(Fla) residues at the hydrophobic side of the four α -helix bundle structure (Figure 1). The 53-peptide exhibi ted the catalyt ic act ivi ty toward the oxidat ion of 1-benzyl-1,4-dihydronicotinamide (Bzl-NAH) in the presence of sodium dodecylsulfate (SDS) [1]. Instead of the addition of a surfactant, we modified the substrate with various alkyl chains to evaluate the specificity. In addition, in order to compare the positioning of Cys(Fla) on the amphiphilic α-helix, we synthesized the related 53-peptides with different sequences for Cys (Figure 1A). |
