Current status, new frontiers and challenges in radiation biodosimetry using cytogenetic, transcriptomic and proteomic technologies

Autor:	Michael Fenech
Rok vydání:	2011
Předmět:	Oncology Toxicology medicine.medical_specialty Radiation Medical treatment Biodosimetry business.industry Exposed Cohort Internal medicine Medicine business Instrumentation
Zdroj:	Radiation Measurements. 46:737-741
ISSN:	1350-4487
DOI:	10.1016/j.radmeas.2011.01.016
Popis:	Biodosimetric methods for determining exposure dose in individuals following a radiation accident are important for the health management of the exposed cohort and prioritisation of high dose exposure cases to receive emergency medical treatment. This brief review provides a succinct outline of (i) the current status of standard cytogenetic methods used in radiation biodosimetry; (ii) development of high-throughput systems for current standard cytogenetic methods; (iii) emerging minimally invasive methods; (iv) the impact of nutrition and genotype on observed dose–response relationships and (v) new frontiers in biodosimetry using molecular biology techniques such as transcriptomics and proteomics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bac4be24283548c191c61281a6fead4a https://doi.org/10.1016/j.radmeas.2011.01.016 Zobrazit plný text záznamu Full Text from ScienceDirect