Pulmonary melanocytic nevus – A case report with a mutation analysis of common driver oncogenes

Autor:	Shigeaki Umeda, Kenichi Ohashi, Hideaki Mitsui, Toshiaki Kataoka, Koji Okudela, Yui Kojima, Takehisa Suzuki, Naomi Kawano, Hiroyuki Osawa, Yoko Tateishi, Meiro Tanaka, Chihiro Koike, Mai Matsumura
Rok vydání:	2019
Předmět:	0301 basic medicine Pathology medicine.medical_specialty Esophageal mucosa Conjunctiva integumentary system business.industry Melanoma General Medicine Melanocytic nevus medicine.disease Pathology and Forensic Medicine BRAF V600E 03 medical and health sciences BRAF Gene Mutation 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine Mutation testing skin and connective tissue diseases business neoplasms V600E
Zdroj:	Pathology International. 69:667-671
ISSN:	1440-1827 1320-5463
DOI:	10.1111/pin.12850
Popis:	Nevi are benign melanocytic tumors, and some nevi are considered to develop into malignant melanomas. Most nevi arise in the skin, but nevi occasionally occur in the conjunctiva, esophageal mucosa, or at other sites. Pulmonary melanocytic nevi are extremely rare, and only one case has been reported in the literature. Here, we present a case of pulmonary melanocytic nevus, involving a BRAF gene mutation (V600E), and we discuss the potential significance of this condition as a precursor to pulmonary malignant melanoma.
Databáze:	OpenAIRE
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