Synthesis and antimicrobial activity of 2-alkyl-1-[2′-chloro(diethylamino, morpholino)methylcarbonylethoxy]pyrroles

Autor:	Sh. F. Nagieva, R. I. Ibragimov, R. A. Hajili, Z. O. Karaev, S. K. Zeinalova, R. F. Gakhramanov, T. S. Mekhtieva, A. A. Mamedova
Rok vydání:	2010
Předmět:	Pharmacology chemistry.chemical_classification Diethylamine Morpholino Pharmacology toxicology chemistry.chemical_element Chloroacetyl chloride Antimicrobial chemistry.chemical_compound chemistry Morpholine Drug Discovery Chlorine Organic chemistry Alkyl
Zdroj:	Pharmaceutical Chemistry Journal. 44:430-432
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-010-0484-8
Popis:	A series of previously unreported 2-alkyl-1-(2-chloromethylcarbonylethoxy)pyrroles have been synthesized via reaction of 2-alkly-1-(2-hydroxyethyl)pyrroles with chloroacetyl chloride and reaction of the intermediates with secondary amines to give 2-alkyl-1-[2-diethylamino(morpholino)methylcarbonylethoxy]pyrroles. Their antimicrobial activity has been studied. It is established that electron-accepting substituents in the methylcarbonylethoxy chain increase whereas electron-donating ones decrease the antimicrobial activity of the pyrroles in the order chlorine > morpholine > diethylamine.
Databáze:	OpenAIRE
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