Synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones

Autor:	Angelina V. Biitseva, Tetyana Yegorova, Andrii I. Kysil, Oleksandra Bugera, Zoia Voitenko
Rok vydání:	2020
Předmět:	chemistry.chemical_compound 010405 organic chemistry Drug discovery Chemistry Pharmacophore 010402 general chemistry 01 natural sciences Flavanone Combinatorial chemistry 0104 chemical sciences
Zdroj:	French-Ukrainian Journal of Chemistry. 8:176-182
ISSN:	2312-3222
DOI:	10.17721/fujcv8i2p176-182
Popis:	Simple and efficient synthesis of 2-(1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones is elaborated. The method relies on CDI-mediated cyclocondensation of substituted 4-oxochromane-2-carboxylic acids and amidoximes. The protocol allows the preparation of 2-oxadiazolylchromanones decorated with two pharmacophores (2,3-dihydro-4H-chromen-4-one and 1,2,4-oxadiazole) that are in high demand in drug discovery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bab1ff2b2c3fca8a2de54342d48f0903 https://doi.org/10.17721/fujcv8i2p176-182 Zobrazit plný text záznamu