Trihexyphenidyl induced malignant hyperthermia in a patient with Parkinson's disease complicated with pneumonia
| Autor: | Congrui Feng, Wei Ma, Yanhong Kang, Gang Xu, Jun Zhao, Yuluo Chen, Feng Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Hyperthermia
Pediatrics medicine.medical_specialty Side effect Trihexyphenidyl business.industry Malignant hyperthermia General Medicine medicine.disease 03 medical and health sciences Pneumonia 0302 clinical medicine 030220 oncology & carcinogenesis Syndrome of inappropriate antidiuretic hormone secretion medicine 030212 general & internal medicine Adverse effect Hyponatremia business medicine.drug |
| Zdroj: | Medicine. 99:e20129 |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Introduction Drug-induced fever is easy to overlook in respiratory departments. High fever is a rare side effect of trihexyphenidyl, which can be used clinically to treat Parkinson's disease. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a group of clinical syndromes caused by various diseases, resulting in water retention and refractory hyponatremia. However, pneumonia combined with malignant hyperthermia and SIADH has rarely been reported. We describe an unusual case of malignant hyperthermia and refractory hyponatremia due to trihexyphenidyl adverse reaction. Patient concerns Fifty-five-year-old male with pneumonia presented with malignant hyperthermia and refractory hyponatremia has a history of Parkinson's disease. Diagnosis Early considerations related the described hyperthermia findings to the manifestations of pneumonia. However, the last findings were due to trihexyphenidyl adverse reaction. Interventions Broad-spectrum antibiotics, oral and intravenous supplement of concentrated sodium chloride, drug, and physical cooling. Outcomes The patient survived. During the 3-month follow up, the patient was no recurrence of fever or hyponatremia. Conclusion High fever and SIADH can be a rare adverse reaction to trihexyphenidyl. Therefore, possible drug factors should be considered in the case. Consideration of other possible causes can improve early diagnosis and treatment of patients with fever of unknown origins. |
| Databáze: | OpenAIRE |
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