Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation

Autor:	Douglas A. Drossman, J. F. Johanson, R. Panas, A. Wahle, Ryuji Ueno
Rok vydání:	2008
Předmět:	medicine.medical_specialty Constipation Hepatology business.industry Gastroenterology Phases of clinical research Placebo medicine.disease Lubiprostone Clinical trial Quality of life Internal medicine Medicine Effective treatment Pharmacology (medical) medicine.symptom business Irritable bowel syndrome medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 27:685-696
ISSN:	1365-2036 0269-2813
DOI:	10.1111/j.1365-2036.2008.03629.x
Popis:	SUMMARY Background Analyses of a trial in constipated patients indicated that lubiprostone may be an effective treatment for irritable bowel syndrome with constipation. Aim To assess the efficacy and safety of three lubiprostone doses for irritable bowel syndrome with constipation. Methods 195 irritable bowel syndrome with constipation patients received daily doses of 16 [8 lg twice daily (b.d.)], 32 (16 lg b.d.) or 48 lg (24 lg b.d.) lubiprostone or placebo b.d. for 3 months. Gastrointestinal parameters were recorded in diaries daily by patients. Results
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::baacca032537efae7e91f35d48ff73f2 https://doi.org/10.1111/j.1365-2036.2008.03629.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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