Comparative Significance of p53 and WAF/l-p2 1 Expression on the Efficacy of Adjuvant Chemotherapy for Resectable Invasive Ductal Carcinoma of the Pancreas
| Autor: | Yoshinori Nio, Chikage Iguchi, Michio Takamura, Susumu Sasaki, Katsuhiro Tamura, Noriyuki Hirahara, Yoshimitsu Minari, Ming Dong, Ken Uegaki |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Oncology
Chemotherapy medicine.medical_specialty Pancreatic disease Hepatology Cyclophosphamide Endocrinology Diabetes and Metabolism medicine.medical_treatment Ductal carcinoma Biology medicine.disease Endocrinology medicine.anatomical_structure Pancreatic cancer Internal medicine Pancreatectomy Internal Medicine medicine Cancer research Pancreas Survival analysis medicine.drug |
| Zdroj: | Pancreas. 18:117-126 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/00006676-199903000-00002 |
| Popis: | Summary p53 tumor-suppressor gene has a dual role as a trigger of apoptosis and as an initiator of DNA repair. The cyclin-dependent kinase inhibitor WAF/1-p21 is induced by wild-type p53 and has been implicated as a downstream mediator of the growth-suppressing and apoptosis-promoting function of wild-type p53, suggesting an impact on the effectiveness of chemotherapy. This study was designed to assess the significance of p53 and WAF/I-p21 expression in the prognosis of patients and the efficacy of adjuvant chemotherapy for resectable invasive ductal carcinoma (IDC) of the pancreas. A total of 58 patients with primary IDC of the pancreas underwent pancreatectomy between 1982 and 1996: 28 patients underwent surgery alone, and 30 patients received postsurgical adjuvant Chemotherapy p53 and WAF/I-p21 were stained immunohistochemically with anti-p53 monoclonal antibody (mAb) and anti-WAF/I-p21 mAb. p53 was positively expressedin 29 (50%) of 58 primary lesions, and p21 was expressed in 24 (41%) lesions; however, p21 expression did not necessarily correlate with p53 expression. The survival curve of the patients with p53(+) IDC was significantly lower than that of those with p53(-) IDC, and p21(+) patients showed a higher survival curve than did p2 1 (-) patients, but this difference was not statistically significant. When p53 and p21 expression were analyzed in combination, the patients with p53(+)p21(-) IDC were found to have a significantly poorer prognosis than others. On the other hand, the survival curve of the adjuvant chemotherapy group was also higher than that of the surgery-alone group, but this difference was not significant. In a multivariate analysis, p21 expression was a significantly low risk factor for death due to IDC overall, and adjuvant chemotherapy was found to decrease the risk of death from IDC in p53(+) patients. Evaluation of expression of p53 and WAF/l-p21 may be beneficialin the prediction of the patient's prognosis as well as prediction of the effects of adjuvant chemotherapy in pancreatic cancer patients. |
| Databáze: | OpenAIRE |
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