BIOSYNTHESIS OF PROINSULIN AND INSULIN BY THE CHICK EMBRYO PANCREAS FROM LABELLED AMINO ACID
| Autor: | A. Akin-Deko, T. Adesanya Ige Grillo |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty animal structures Pancreatic Extracts Insulin medicine.medical_treatment Embryo Biology Embryonic stem cell Amino acid chemistry.chemical_compound Endocrinology medicine.anatomical_structure Biosynthesis chemistry Internal medicine embryonic structures medicine Pancreas Proinsulin |
| DOI: | 10.1016/b978-0-08-021257-9.50012-7 |
| Popis: | Publisher Summary Protein, also called pro-insulin, is extracted from the pancreas of various vertebrates such as beef pro-insulin, porcine pro-insulin, rat pro-insulin, and cod pro-insulin. While there is no reason to expect that the method of synthesis of insulin in chicken is different from that of the other method, in which the synthesis of insulin is obtained in other vertebrates, yet it is important to ascertain that in the development of the pancreas, the β cells from the beginning also make pro-insulin from which insulin is formed. The chick embryonic pancreas could produce in large quantity insulin from the 12th day of incubation, while the gut-pancreas complex of the chick embryo could synthesize insulin earlier. The chick embryonic pancreas also synthesized insulin from the precursor pro-insulin and the rate is similar to that of adult vertebrates. From the chromatography of the chick embryo pancreatic extracts, it is suggested that chick embryo insulin is probably heavier than bovine insulin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|