Thermodynamic Models for Determination of the Solubility of Boc-(R)-3-Amino-4-(2, 4, 5-trifluorophenyl)butanoic acid in Different Pure Solvents and (Tetrahydrofuran + n-Butanol) Binary Mixtures with Temperatures from 280.15 to 330.15 K
| Autor: | Shimin Fan, Jianfeng Hao, Wenge Yang, Yonghong Hu, Hongjie Li, Shouhai Yang, Qirun Guo |
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| Rok vydání: | 2016 |
| Předmět: |
Atmospheric pressure
General Chemical Engineering Ethyl acetate 02 engineering and technology General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Propanol chemistry.chemical_compound 020401 chemical engineering chemistry n-Butanol Physical chemistry Gravimetric analysis Organic chemistry Methanol 0204 chemical engineering Solubility Tetrahydrofuran |
| Zdroj: | Journal of Chemical & Engineering Data. 61:1109-1116 |
| ISSN: | 1520-5134 0021-9568 |
| Popis: | A gravimetric method was taken to measure the solubility of the Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid under atmospheric pressure in methanol, ethanol, propanol, n-butanol, ethyl acetate, and tetrahydrofuran as well as in the (tetrahydrofuran + n-butanol) mixtures from 280.15 to 330.15 K.The experiment results have proved that the rising temperature leads to increased solubility of the Boc-(R)-3-amino-4- (2,4,5-trifluorophenyl)butanoic acid in all selected solvents. The solid–liquid equilibrium data in pure and mixed solvents is correlated with a series of equations, including the modified Apelblat equation, the Buchowski–Ksiazaczak λh equation, CNIBS/R–K equation and the Jouyban–Acree equation. During the study, the computational values were in good agreement with the experimental results according to the calculations based on all selected equations, however, the modified Apelblat equation stood out to be the higher suitable with the higher accuracy. The thermodynamic properties of the so... |
| Databáze: | OpenAIRE |
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